紫茉莉块根提取物对洛哌丁胺诱导便秘小鼠的治疗作用

doi:10. 3969 / j. issn. 2096-2266. 2026. 02. 014

大理大学学报 ›› 2026, Vol. 11 ›› Issue (2): 86-91.DOI: 10. 3969 / j. issn. 2096-2266. 2026. 02. 014

紫茉莉块根提取物对洛哌丁胺诱导便秘小鼠的治疗作用

孟　杨，苏　婷，文晓雪，曹永姗，张福琴，邓信苹，郭美仙*

（大理大学药学院，云南大理　671000）

收稿日期:2025-04-15 修回日期:2025-04-30 出版日期:2026-02-15 发布日期:2026-03-19
通讯作者: 郭美仙，高级实验师，E-mail：310547786@qq.com。
作者简介:孟杨，2022级药学专业本科生。
基金资助:
云南省大学生创新创业训练计划项目（S202310679087）

Therapeutic Effects of Mirabilis jalapa Root Extract on Loperamide-Induced Constipation in Mice

Meng Yang, Su Ting, Wen Xiaoxue, Cao Yongshan, Zhang Fuqin, Deng Xinping, Guo Meixian*

(College of Pharmacy, Dali University, Dali, Yunnan 671000, China)

Received:2025-04-15 Revised:2025-04-30 Online:2026-02-15 Published:2026-03-19

摘要/Abstract

摘要： 目的：观察紫茉莉块根提取物对洛哌丁胺诱导便秘小鼠的改善作用，为开发利用和治疗便秘提供实验依据。方法：采
用洛哌丁胺灌胃构建小鼠便秘模型，将小鼠随机分为正常组、模型组、阳性组及紫茉莉提取物低、中、高剂量组，连续给药7 d。
通过记录一般状态、首粒黑便排出时间、6 h粪便颗粒数及粪便含水率评价排便功能；应用酚红法检测胃内酚红残留量及小肠
转运率；测定结肠含水率评估结肠含水状况。结果：与正常组比较，模型组小鼠首粒黑便排出时间显著延长，6 h粪便颗粒数及
粪便、结肠含水率明显下降，胃内酚红残留量增加，小肠转运率降低（P<0.05），表明模型构建成功。与模型组比较，紫茉莉中、
高剂量组均可显著缩短首粒黑便排出时间，显著增加6 h粪便颗粒数，提高粪便、结肠含水率和小肠转运率（P<0.05），紫茉莉高
剂量组胃内酚红残留量显著降低（P<0.05），提示紫茉莉块根提取物具有促进胃排空与肠道蠕动的作用。结论：紫茉莉块根提
取物可有效改善便秘小鼠排便状况，增强胃排空能力及小肠转运功能，提高粪便与结肠含水率，具有明确的通便及促进胃肠动
力作用。

关键词: 紫茉莉, 便秘小鼠, 胃肠动力, 洛哌丁胺

Abstract: Objective: To investigate the ameliorative effect of Mirabilis jalapa root extract on loperamide-induced constipation in
mice, providing experimental evidence for its development and application in constipation treatment. Methods: A constipation model
was established in mice by intragastric administration of loperamide. The animals were randomly divided into a normal control group, a
model group, a positive control group, and low-, medium-, and high-dose M. jalapa extract groups, with continuous administration for
7 days. Defecation function was assessed by general condition, first black stool excretion time, the number of fecal pellets within 6
hours, and fecal water content. Gastric phenol red retention and small intestinal transit rate were measured using the phenol red
method. Colonic water content was determined to evaluate colonic hydration. Results: Compared with the normal group, the model mice
exhibited a significantly prolonged time to first black stool, reduced fecal pellet number, decreased fecal and colonic water content,
along with increased gastric phenol red retention and decreased intestinal transit rate (P<0.05), confirming successful model establishment.
Compared with the model group, medium- and high-dose M. jalapa extract significantly shortened the time to first black stool,
increased fecal pellet number within 6 hours, and improved fecal and colonic water content as well as small intestinal transit rate (P<
0.05). The high-dose extract also markedly reduced gastric phenol red retention (P<0.05), indicating enhanced gastric emptying and
intestinal motility. Conclusion: M. jalapa root extract effectively relieves constipation in mice, improves gastric emptying and small
intestinal transit function, increases fecal and colonic water content, and exerts a clear laxative effect with gastrointestinal motilitypromoting
potential.

Key words: Mirabilis jalapa, constipated mice, gastrointestinal motility, loperamide

中图分类号:

R285.5

孟　杨, 苏　婷, 文晓雪, 曹永姗, 张福琴, 邓信苹, 郭美仙. 紫茉莉块根提取物对洛哌丁胺诱导便秘小鼠的治疗作用[J]. 大理大学学报, 2026, 11(2): 86-91.

Meng Yang, Su Ting, Wen Xiaoxue, Cao Yongshan, Zhang Fuqin, Deng Xinping, Guo Meixian. Therapeutic Effects of Mirabilis jalapa Root Extract on Loperamide-Induced Constipation in Mice[J]. Journal of Dali University, 2026, 11(2): 86-91.

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紫茉莉块根提取物对洛哌丁胺诱导便秘小鼠的治疗作用

Therapeutic Effects of Mirabilis jalapa Root Extract on Loperamide-Induced Constipation in Mice

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